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MIST Therapy® is a painless, noncontact, low-frequency ultrasound delivered through a saline mist to the wound bed. Unlike most wound therapies that are limited to treating the wound surface, the gentle sound waves of MIST Therapy stimulate the cells within and below the wound bed to accelerate the normal healing process.

The result of these gentle sound waves pushing against the tissue include:

Removal of Barriers to Healing

  • Reduces a wide-range of bacteria (1, 2)
  • Disrupts biofilm (3)
  • Reduces sustained inflammation (4, 5)
  • Reduces MMP-9 (5)

Stimulates Cells to Promote Healing

  • Increased blood flow through vasodilation (6)
  • Increased angiogenesis (7,8)
  • Early release of growth factors (5, 9)
  • Increased collagen deposition (8)

For additional product information and clinical research, visit MistTherapy.com >>

REFERENCES

  1. Serena T, et al. The Impact of Noncontact, Nonthermal,Low-Frequency Ultrasound on Bacterial Counts in Experimental and Chronic Wounds. Ostomy Wound Management 2009;55(1):22-30.
  2. Kavros SJ, Schenck EC. Use of Noncontact Low-Frequency Ultrasound in the Treatment of Chronic Foot and Leg Ulcerations: A 51 Patient Analysis. JAPMA 2007;97(2):95-101.
  3. Seth AK, Mustoe TA, Galiano RD, et al. Noncontact,low-frequency ultrasound as an effective therapy against Pseudomonas aeruginosa–infected biofilm wounds. Wound Repair & Regeneration. 2013;21(2):266-274.
  4. Escandon J, Vivas AC, Perez R, Kirsner R, Davis S. A Prospective Pilot Study of Ultrasound Therapy Effectiveness in Refractory Venous Leg Ulcers. International Wound Journal 2012;9(5):570-578.
  5. Yao M, Hasturk H, Kantarci A, Gu G, Garcia-Lavin S, Fabbi M, Park N, Hayashi H, Attala K, French MA, Driver VR. A Pilot Study Evaluating Noncontact Low Frequency Ultrasound and Underlying Molecular Mechanism on Diabetic Foot Ulcers. International Wound Journal 2014;11(6):586-593.
  6. Ennis WJ, Valdes W, Gainer M, Meneses P. Evaluation of Clinical Effectiveness of MIST Ultrasound Therapy for the Healing of Chronic Wounds. Adv Skin Wound Care 2006;19:437-46
  7. Maan ZN, Januszyk M, Rennert C, Duscher D, Rodrigues M, Fujiwara T, Ho N, Whitmore A, Hu MS, Longaker MT, Gurtner GC. Noncontact, Low-Frequency Ultrasound Therapy Enhances Neovascularization and Wound Healing in Diabetic Mice. Plastic and Reconstructive Surgery. 2014: 134: 402e – 411e
  8. Thawer HA, Houghton PE. Effects of Ultrasound Delivered Through a Mist of Saline to Wounds in Mice with Diabetes Mellitus. J Wound Care. 2004;13(5):1–6.
  9. Lai JY, Pittelkow MR. Physiological Effect of Ultrasound Mist on Fibroblasts. Int J Dermatol. 2007;46(6):587-593.

INTELLECTUAL PROPERTY

Notice is hereby provided by way of this Virtual Patent Mark per 35 U.S.C. § 287(a) that the Celleration Inc. products or portions thereof listed below are covered under one or more patents in the United States or elsewhere. Additional patents may be pending in the United States or elsewhere.

Last updated: July 20, 2015

Wound Care

MIST Therapy® System, UltraMIST System, MIST Therapy® Applicator, MIST 360° Applicator, and UltraMIST Applicator

In the United States:

MIST® Systems (includes MIST Therapy® System and UltraMIST System), methods and devices or portions thereof are protected by one or more of the following United States Patents: 6,478,754; 6,533,803; 6,569,099; 6,601,581; 6,663,554; 6,761,729; 6,960,173; 7,914,470; 8,235,919; D733,319; D733,321
MIST Therapy Applicator, MIST 360° Applicator and UltraMIST Applicator or portions thereof are protected by one or more of the following United States Patents: 6,964,647; 7,713,218; 7,785,277; D733,319; D733,321

In Countries other than the United States:

Patents marked as “EPXXXXXX” denote a European Patent number. Inclusion of this number in a specific country list provides that the EP patent post grant is validated in that country.

In France:

MIST Systems, methods and devices or portions thereof are protected by one or more of the following French Patents: EP1355696; EP1322275

In Germany:

MIST Systems, methods and devices or portions thereof are protected by one or more of the following German Patents: EP1355696; EP1322275

In United Kingdom:

MIST Systems, methods and devices or portions thereof are protected by one or more of the following United Kingdom Patents: EP1355696; EP1322275

In Canada:

MIST Systems, methods and devices or portions thereof are protected by one or more of the following Canadian Patents: CA2463600; CA2521117

In China:

MIST Systems, methods and devices or portions thereof are protected by one or more of the following Chinese Patents: CN1466445

In India:

MIST Systems, methods and devices or portions thereof are protected by one or more of the following Indian Patents: IN207058; IN228689

In Japan:

MIST Systems, methods and devices or portions thereof are protected by one or more of the following Japanese Patents: JP4164582

In Singapore:

MIST Systems, methods and devices or portions thereof are protected by one or more of the following Singapore Patents: SG95385